In a large bowl, whisk together the flour, sugar, baking powder, baking soda, and salt.
In another bowl, combine the buttermilk, egg, and melted butter.
Pour the wet ingredients into the dry ingredients and mix until just combined.
Heat a non-stick skillet over medium heat and lightly grease with cooking spray or butter.
Pour 1/4 cup of batter onto the skillet for each pancake.
Cook until bubbles form on the surface, about 2-3 minutes.
Flip the pancakes and cook for an additional 2-3 minutes until golden brown.
Repeat with the remaining batter, adjusting heat as necessary.
Serve warm with your favorite toppings.
Enjoy your fluffy buttermilk pancakes!